Shaq Lawson Jerseys Stitched , 1 p.m. ET, CBSOPENING LINE — Chargers by 7 1/2RECORD VS. SPREAD — Los Angeles 0-1, Buffalo 0-1SERIES RECORD — Chargers lead 24-12-2LAST MEETING — Chargers beat Bills 54-24, Nov. 19, 2017LAST WEEK — Chargers lost to Chiefs 38-28; Bills lost to Ravens 47-3AP PRO32 RANKING — Chargers No. 19, Bills No. 32CHARGERS OFFENSE — OVERALL (1), RUSH (11), PASS (2).CHARGERS DEFENSE — OVERALL (20), RUSH (13), PASS (22).BILLS OFFENSE — OVERALL (32), RUSH (25), PASS (32).BILLS DEFENSE — OVERALL (22) Youth Frank Gore Jerseys , RUSH (19), PASS (21).STREAKS, STATS AND NOTES — Chargers coach Anthony Lynn served as Bills interim coach for 2016 season finale after Rex Ryan was fired. Lynn was candidate for Bills job before Sean McDermott got it. … Chargers have won three straight and 17 of past 22 meetings. … Chargers have outscored Bills by combined 113-44 in past three meetings, and not trailed since 23-14 loss on Oct. 19, 2008. … QB Philip Rivers is 4-1 against Bills with 1,115 yards passing, 10 touchdowns and one interception. With 424 yards passing against Chiefs, Rivers topped 400 yards for 10th time — tied for fourth on NFL career list. … RB Melvin Gordon had career-best 102 yards receiving against Chiefs. … CB Casey Hayward intercepted two of Bills QB Nathan Peterman’s five first-half interceptions in last meeting. … Bills first-round pick QB Josh Allen to make first career start after Peterman went 5 of 18 for 24 yards and two interceptions in two-plus quarters against Ravens. … Bills traded up five spots to select Allen out of Wyoming — highest in draft order Buffalo has chosen QB. Allen finished 6 of 15 for 74 yards and 26 yards rushing last week. … Bills only NFL team to not score TD in Week 1. … RB LeSean McCoy had 22 yards rushing on seven carries, and one catch for minus-1 yard. … Loss to Ravens was Bills’ second-most lopsided margin of defeat, behind 56-10 loss to New England on Nov. 18, 2007. … Buffalo managed 153 yards offense against Ravens, fewest since 145 in 40-7 loss at Chicago on Oct. 8 Frank Gore Jerseys Stitched , 2006. … Defense allowed Ravens to score six touchdowns on six trips inside 20. … First-round pick LB Tremaine Edmunds became Bills’ first rookie to have sack in season opener since 2002. … Fantasy Tip: Pick your poison with Rivers and Gordon both having chances of putting up big numbers. Chargers’ defense worth consideration against Bills popgun attack and patchwork offensive line.Five Buffalo Bills players to watch against the Tennessee Titans After an embarrassment in Green Bay, the Buffalo Bills will look to bounce back at home against the Tennessee Titans. The Titans come in at 3-1 with two convincing wins against the Jacksonville Jaguars and the Philadelphia Eagles. Last week, the offense was terrible and the defense did what they could to stop the bleeding.These five players could be key to the Bills success on Sunday:QB Josh AllenAllen is going to be on this list all year and I shouldn't have to spell out why. He struggled mightily last game, whether it was being wildly inaccurate, holding the ball to long and taking the sack, or trying to make too much out of something that is nothing. All of those things are what we expected from Allen when he was drafted since that was a big part of his game at Wyoming. However, week to week improvements are vital to see how he will progress as an NFL quarterback. Offensive coordinator, Brian Daboll, needs to get Allen into a rhythm early to set the tone for the length of the game. RB LeSean McCoyMcCoy has been nonexistent through the first three games he appeared in. Through those three games he has just 29 total touches for 126 yards—not ideal for what is supposed to be your best offensive player. However the Bills can get the ball in his hands, they need to do it. WR Zay JonesI don't expect much more from Kelvin Benjamin as a reliable target for Josh Allen but Jones has shown a glimmer of hope on a handful of occasions. He hasn't been targeted much but when he is, the result is usually a positive outcome. As unimpressive as it is, he is their leading receiver with 10 catches for 144 yards on the season. I’d expect Allen to give him more opportunities to make plays with the ball in his hands. DE Jerry HughesAfter a two-sack performance in Week three Youth Adolphus Washington Jerseys , Hughes and the rest of the pass rushers were no where to be found against the Packers. Given, there were multiple times where the Bills defensive line was being pulled to the turf, they need to be better. It all starts with Hughes, as he has been the best pass rusher on the Bills for the past few years. Hughes has his work cut out for him in his matchup against Titans’ left tackle, Taylor Lewan, one of the top left tackles in the NFL. CB Taron JohnsonJohnson has been a bright spot for the Bills, much like Matt Milano was last season and a mid-round rookie. As the starting nickel corner, Johnson is rarely out of position and makes a lot of tough open field tackles. Last week, Johnson was by far the best player on both sides of the ball for the Bills. With a decent receiving corps and two good running backs, Johnson could have another busy day in the slot.